The Milan-Fiorentino clash kicks off at 19:00 CET on Sunday, with the result set to be announced at the time of the game.
Here’s what you need to know about the clash: What are the key match-ups?
It is a first leg at the San Siro for both sides.
Fiorettina face a weakened side that has lost six of its last seven games, while Inter Milan have just a single win from their last 10 league matches.
Inter are also without defender Andrea Pirlo for the match after the Italian international was sent off in a 3-2 defeat at Napoli on Saturday.
Who is the big draw?
The home side are the favourites for the first leg, with their form under Gianluca Vialli in recent months helping them to two successive Serie A titles.
The Nerazzurri have lost just one of their last five meetings with the Rossoneri, with both sides winning all three of their encounters.
Inter have lost all of their meetings with Fiorendina this season, having been the hosts in all three contests.
Where are the top scorers?
In the last three matches, Andrea Pignatelli has netted five goals and seven assists in Serie A. The Italian striker has also scored five goals in seven games against Fiorence this season.
Inter’s Paulo Dybala, who has six goals and five assists in 17 games, has scored just two goals in his last five games against the Rossoni.
Who has the better goal difference?
The two teams are both in the top half of the table at the moment, but Inter have the advantage in terms of goals scored.
They have scored just one more goal than Fiorencer in their last six meetings, and have scored six more than Milan.
What is the line-up?
Inter have won all five of their home matches at the Stadio Olimpico, with a win in all but one of them.
The hosts have not lost at the Vicente Calderon since March 3, with victory in the last meeting in September.
Fiores have conceded just two more goals in their three meetings with Milan this season and have lost one of those.
Who will score?
Milan’s Paulo De Silvestro is expected to start in goal, while Andrea Pincarini has been in the starting line-ups for all of the matches this season with a goal against Juventus on Sunday.
Inter will be without Dani Carvajal (leg) and Claudio Marchisio (groin), while Alessandro Del Piero will start in defence.
Goalkeeper Vincenzo Montella has been sidelined with a knee injury, while Rossonerio midfielder Andrea Palazzi is a doubt.